Semax | Peptide Encyclopedia | Auryx

Semax is a physician-reviewed Auryx Learn encyclopedia entry. A synthetic ACTH 4–7 fragment that upregulates BDNF and improves working memory, focus, and neuroplasticity. This page is educational. It is not a dosing guide and not a substitute for a licensed clinician.

How it works

Semax is a heptapeptide derived from the ACTH 4–7 sequence with additional modifications for stability. It significantly upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), promotes synaptogenesis, and modulates dopaminergic and serotonergic pathways. It also has neuroprotective effects in hypoxic and ischemic conditions.

Used by professionals and biohackers for cognitive performance, and clinically in Russia for post-stroke recovery and neurodegenerative support.

Extensively studied for its effects on BDNF expression, neuroplasticity, and neuroprotection under hypoxic conditions in preclinical models. Significant published research base.

Clinic context and next steps

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