MOTS-c | Peptide Encyclopedia | Auryx
MOTS-c is a physician-reviewed Auryx Learn encyclopedia entry. A mitochondrial-derived peptide that activates AMPK pathways to improve metabolic flexibility, insulin sensitivity, and cellular energy. This page is educational. It is not a dosing guide and not a substitute for a licensed clinician.
How it works
MOTS-c is encoded in the mitochondrial genome and acts as a metabolic regulator by activating AMP-activated protein kinase (AMPK). This improves glucose uptake in muscle cells independent of insulin, increases fatty acid oxidation, reduces oxidative stress, and mimics some beneficial metabolic effects of exercise at the cellular level.
- Improved insulin sensitivity and glucose regulation
- Increased fatty acid oxidation for energy
- Exercise-like metabolic effects at cellular level
- Longevity-associated pathway activation
- Anti-inflammatory and antioxidant effects
Used in metabolic optimization, longevity, and age-related insulin resistance protocols. Particularly relevant for individuals with metabolic dysregulation.
Clinic context and next steps
Pair this entry with the matching shop listing when Auryx offers the compound, or browse the full encyclopedia. Category shopping lives under shop. Mechanism language is not a personal outcome and does not approve a protocol.
Auryx is an MD-led telemedicine clinic. Eligible patients complete remote intake; compounds ship from regulated United States compounding pharmacies after clinical review. Use the protocol finder if you are matching a goal, our method for the four-step process, and about for physician leadership. Citations sit on sources. Questions go to contact or info@auryxlife.com.
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